CasNo： 15318-45-3
MF： C12H15Cl2NO5S
Appearance： off-white solid
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Thiamphenicol is off-white solid, while it's Molecular Formula is C12H15Cl2NO5S. Thiamphenicol, also known as thiophenicol or dextrosulphenidol, is an antibiotic that is a semi-synthetic derivative of chloramphenicol. It exhibits a broad spectrum of antibacterial activity against both Gram-positive and Gram-negative bacteria, including some multidrug-resistant strains. Thiamphenicol works by interfering with bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing the formation of peptide bonds and thereby inhibiting protein translation.
The CAS number of Thiamphenicol is 15318-45-3.
More information of Thiamphenicol 15318-45-3 are:
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Synonyms |
Acetamide,2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl]-,[R-(R*,R*)]-;(Methylsulfonyl)chloramphenicol;8065CB;D-Thiocymetin;D-Thiophenicol;D-d-threo-2-Dichloroacetamido-1-(4-methylsulfonylphenyl)-1,3-propanediol;Dextrosulphenidol;NSC 522822;Thiocymetin;Thiophenicol;Win 5063-2; |
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CAS Number |
15318-45-3 |
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Molecular Formula |
C12H15Cl2NO5S |
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Molecular Weight |
356.227 |
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Density |
1.491 g/cm3 |
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Melting Point |
163-166 °C |
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Boiling Point |
695.9 °C at 760 mmHg |
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Flash Point |
374.7 °C |
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HS CODE |
29414000 |
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PSA |
112.08000 |
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LogP |
1.87600 |
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Pka |
11.05±0.46(Predicted) |
Thiamphenicol's primary function is as a broad-spectrum antibiotic used to treat bacterial infections. It is particularly effective against both Gram-positive and Gram-negative bacteria, including some strains that are resistant to other antibiotics. It achieves this by binding to the 50S ribosomal subunit within bacterial cells, blocking a crucial step in protein chain formation (peptidyl transferase activity).
InChI:InChI=1/C12H14Cl2N2O7S/c1-24(21,22)23-6-9(15-12(18)11(13)14)10(17)7-2-4-8(5-3-7)16(19)20/h2-5,9-11,17H,6H2,1H3,(H,15,18)/t9-,10-/m1/s1
Articles related to Thiamphenicol:
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Article |
Source |
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Regioselective preparation of thiamphenicol esters through lipase-catalyzed processes |
Da Silva, Marcos R.,Montenegro, Tasso G.C.,De Mattos, Marcos C.,De Oliveira, Maria Da Conceic?a?o F.,De Lemos, Telma L.G.,De Gonzalo, Gonzalo,Lavandera, Iva?n,Gotor-Ferna?ndez, Vicente,Gotor, Vicente , p. 987 - 994 (2014) |
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Method for continuously preparing thiamphenicol by using micro-reaction system |
- Paragraph 0021-0043, (2021/08/14) |
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