What is the Flubendazole?

Flubendazole is almost white powder, while it's Molecular Formula is C16H12FN3O3. almost white powder VETRANAL? analytical standard can be used in the liquid chromatography coupled to mass spectrometry (LC-MS/MS) procedure, performed for the analysis of macrocyclic lactones in milk.

What is the CAS number for Flubendazole?

The CAS number of Flubendazole is 31430-15-6.

What is Flubendazole (31430-15-6) used for?

Flubendazole is a benzimidazole carbamate anthelmintic. It completely eliminates larvae in a mouse model of A. cantonensis infection and exhibits a mean larval reduction of 100% in a T. spiralis infection model when administered at doses of 5 and 50 mg/kg per day, respectively. Flubendazole inhibits mammalian tubulin polymerization (IC50 = 2.5 μM) and inhibits binding of [3H]mebendazole to H. contortus L3 larval tubulin (IC50 = 0.17 μM). Flubendazole also inhibits the proliferation of BT-549, SK-BR-3, MDA-MB-231, and MCF-7 breast cancer cells (IC50s = 0.72, 1.51, 1.75, and 5.51 μM, respectively) and reduces tumor growth in an MDA-MB-231 mouse xenograft model when administered at a dose of 25 mg/kg.InChI:InChI=1/C16H12FN3O3/c1-23-16(22)20-15-18-12-7-4-10(8-13(12)19-15)14(21)9-2-5-11(17)6-3-9/h2-8H,1H3,(H2,18,19,20,22)

What is the Flubendazole?

Flubendazole is almost white powder, while it's Molecular Formula is C16H12FN3O3. almost white powder VETRANAL? analytical standard can be used in the liquid chromatography coupled to mass spectrometry (LC-MS/MS) procedure, performed for the analysis of macrocyclic lactones in milk.

What is the CAS number for Flubendazole?

The CAS number of Flubendazole is 31430-15-6.

What is Flubendazole (31430-15-6) used for?

Flubendazole is a benzimidazole carbamate anthelmintic. It completely eliminates larvae in a mouse model of A. cantonensis infection and exhibits a mean larval reduction of 100% in a T. spiralis infection model when administered at doses of 5 and 50 mg/kg per day, respectively. Flubendazole inhibits mammalian tubulin polymerization (IC50 = 2.5 μM) and inhibits binding of [3H]mebendazole to H. contortus L3 larval tubulin (IC50 = 0.17 μM). Flubendazole also inhibits the proliferation of BT-549, SK-BR-3, MDA-MB-231, and MCF-7 breast cancer cells (IC50s = 0.72, 1.51, 1.75, and 5.51 μM, respectively) and reduces tumor growth in an MDA-MB-231 mouse xenograft model when administered at a dose of 25 mg/kg.InChI:InChI=1/C16H12FN3O3/c1-23-16(22)20-15-18-12-7-4-10(8-13(12)19-15)14(21)9-2-5-11(17)6-3-9/h2-8H,1H3,(H2,18,19,20,22)

Factory supply Flubendazole 31430-15-6 with sufficient production capacity

Product NameFlubendazole
CasNo. 31430-15-6
MFC₁₆H₁₂FN₃O₃
MW313.288
Purity
Appearancealmost white powder
Packing
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Product Details

CasNo： 31430-15-6

MF： C₁₆H₁₂FN₃O₃

Appearance： almost white powder

Factory supply Flubendazole 31430-15-6 with sufficient production capacity

Molecular Formula:C16H12FN3O3
Molecular Weight:313.288
Appearance/Colour:almost white powder
Melting Point:290 °C
Refractive Index:1.685
PKA:10.66±0.10(Predicted)
PSA：84.08000
Density:1.444 g/cm³
LogP:3.18430

Flubendazole(Cas 31430-15-6) Usage

Therapeutic Function	Anthelmintic
Biochem/physiol Actions	Flubendazole, an antithelmintic, has been widely used in treating intestinal parasites. Additionally, Flubendazole has been reported to exert anticancer activities.
Definition	ChEBI: A member of the class of mebendazole in which the benzoyl group is replaced by a p-fluorobenzoyl group. A broad-spectrum anthelmintic, it is used, particularly in veterinary medicine, for the treatment of nematodal infections.
General Description	Flubendazole is a benzimidazole anthelmintic drug that is available from a number of sources. The benzimidazoles are a group of compounds that include albendazole, flubendazole, mebendazole, niridazole, triabendazole, and triclabendazole.
Uses	Flubendazole, belonging to benzimidazole, is a broad-spectrum insect repellent and has been repurposed as a promising anticancer drug. In recent years, many studies have shown that flubendazole plays an anti-tumor role in different types of cancers, including breast cancer, melanoma, prostate cancer, colorectal cancer, and lung cancer.
Who Evaluation	Evaluation year: 1993

InChI:InChI=1/C16H12FN3O3/c1-23-16(22)20-15-18-12-7-4-10(8-13(12)19-15)14(21)9-2-5-11(17)6-3-9/h2-8H,1H3,(H2,18,19,20,22)

31430-15-6 Relevant articles

Flubendazole exhibits anti-glioblastoma effect by inhibiting STAT3 and promoting cell cycle arrest

Barbora Vítovcová, Veronika Skarková, Radim Havelek, Jiří Soukup, Ananya Pande, Kateřina Caltová & Emil Rudolf

Scientific Reports volume 13, Article number: 5993 (2023)

In our study, we demonstrated that repurposed drug flubendazole (FLU) significantly inhibits proliferation and survival of GBM cells. FLU exerted its effect by affecting microtubule structure and our results also suggest that FLU influences tubulins expression to a certain degree.

Flubendazole Plays an Important Anti-Tumor Role in Different Types of Cancers

Chaoran Chen,1,† Yueming Ding,1,† Huiyang Liu,2 Mengyao Sun,3 Honggang Wang,2,* and Dongdong Wu2,4,*

, Int J Mol Sci. 2022 Jan; 23(1): 519.

FLU suppresses breast cancer through the inhibition of proliferation, metastasis and drug resistance mainly by targeting breast CS-like cells via inhibiting cell cycle progression and tubulin polymerization. FLU suppresses TNBC mainly through the inhibition of breast CS-like cells via inhibiting STAT3 activation; FLU mitigates resistance to trastuzumab through the inhibition of CS-like cell properties and the HER2 pathway, and the induction of apoptosis and G2/M phase arrest in HER2-positive breast cancer