• Product NameAmoxicillin Trihydrate
  • CasNo. 61336-70-7
  • MFC16H25N3O8S
  • MW419.456
  • Purity
  • AppearanceA White CRYSTALLINE powder
  • Packing
  • Contact usInquiry

Product Details

CasNo: 61336-70-7

MF: C16H25N3O8S

Appearance: A White CRYSTALLINE powder

Chinese Factory Supply Wholesale Amoxicillin Trihydrate 61336-70-7 with Cheap Price

  • Molecular Formula:C16H19N3O5S*3H2O
  • Molecular Weight:419.456
  • Appearance/Colour:A White CRYSTALLINE powder 
  • Vapor Pressure:3.39E-23mmHg at 25°C 
  • Melting Point:>200oC (dec.) 
  • Refractive Index:302 ° (C=0.1, H2O) 
  • Boiling Point:743.2 °C at 760 mmHg 
  • Flash Point:403.3 °C 
  • PSA:185.95000 
  • Density:1.54g/cm3 
  • LogP:0.85990 
  • IDLH:85 

Amoxicillin trihydrate(Cas 61336-70-7) Usage

Therapeutic Function

Antibacterial

Safety Profile

Moderately toxic. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.

Definition

ChEBI: A hydrate that is the trihydrate form of amoxicillin; a semisynthetic antibiotic, used either alone or in combination with potassium clavulanate (under the trade name Augmentin) for treatment of a variety of bacterial infections.

Uses Amoxicillin sodium is very hygroscopic in nature, while trihydrate is non-hygroscopic. Among free base, sodium salt, and trihydrate, amoxycillin trihydrate is the most stable solid form [14]. Still, amoxicillin trihydrate is sensitive to temperature and humidity. It also shows degradation in alcohol and polyols.

Who Evaluation

Evaluation year: 2017

InChI:InChI=1/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24)/t9-,10-,11+,14?/m1/s1

61336-70-7 Relevant articles

Study on the rate of decomposition of amoxicillin in solid state using high-performance liquid chromatography

R. Méndez,M. T. Alemany,C. Jurado &J. Martin

, Drug Development and Industrial Pharmacy, Volume 15, 1989 - Issue 8

Amoxicillin trihydrate, now used in pharmaceutical formulations, is significantly more stable than sodium amoxicillin. It degrades according to Prout-Tompkins model. We studied the stability of amoxicillin at temperatures of 37°, 50°, 80°, 90°, 100° y 110° C. HPLC was chosen as the analytical method. Amoxicillin and its decomposition products are separated by reversed-phase (C18) HPLC with gradient elution.

Biopharmaceutical study on the oral and rectal administrations of enamine prodrugs of amino acid-like β-lactam antibiotics in rabbits

Murakami,Tamauchi,Yamazaki,Kubo,Kamada,Yata

, p. 1986 - 1997 (2007/10/02)

-

Role of Prophylactic Dose of Oral Amoxicillin Trihydrate in Prevention of Bacteremia Post Surgical Removal of Impacted Mandibular Third Molar: A Clinical Study

Vikrant Dilip Sane, Abhijeet Ranade, Vivek Sunil Nair, Rashmi Vikrant Sane, Pankaj Kadam & Nishita Bhosale

, Indian Journal of Otolaryngology and Head & Neck Surgery, Volume 75, pages 2907–2912, (2023)

Twenty five randomly selected patients (study group) were administered two grams oral dose of amoxicillin trihydrate, one hour prior to the procedure. Twenty five patients (control group) were not administered any antibiotic prior to the procedure.

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